The larger the block, the easier to use, the smaller, the less space required when hard sheeted block to block.
The thicker the sheet, the easier on your hands and therefore less fatigue but bigger blocks. The thinner the sheet usually cheaper and smaller blocks required also cheaper.
On short constantly changing course thinner sheets are ok but marathons with fewer course changes thicker sheets means less fatigue.
If you use a ratchet block this can alleviate a lot of hand discomfort
