Last 4 generations on my fathers side died of heart attacks in their 50's. My father and uncle both would have also, except for quad bypass surgery. Both are skinny as a rake, eat like rabbits, exercise regularly, but had cholesterol readings close to double figures. Following surgery, cholesterol med's have kept their readings down from 9 to 2.5 and now they are both in their late 70's.
At age 45 and with a young family to look after, I was obviously concerned. My chol readings started to take an identical path to my father's, 4, then 5, and then 6. Chol meds brought it down to 2.5, but then they started to destroy my kidneys, so I had to go off them. Doctor suggested I have a heart CAT scan to see just what was happening, so we could then make a more educated decision whether to try other meds, or just stay off them.
They did two scans. One was a calcium scan to show plaque in the arteries, and the other was a radioactive iodine injection into my blood that can then let you see the blood flowing in the arteries, and shows if there are any blockages building up. The second scan is important, as there can be plaque that has not calcified, and therefore would not show up on the calcium scan. The downside of the scan is that I was exposed to the equivalent of 12 months of normal background radiation, an acceptable risk given my age and risk profile.
Expecting the worst, I was then told I am in the 0 percentile risk group, with 100% clear arteries. Life insurance companies would be lining up for my business with the results I had. The doctors explanation..."For some people the cholesterol sticks, for other people it doesn't. We don't know why."
Seems I must have heart genes from my mothers side. (That side of the family all drink, smoke and eat what they like until their late 80's or 90's.) Now I have to put more money in super to fund my longer retirement.